Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
August 2015 Vol. 4(8), pp. 321-330
Copyright © 2015 Global Advanced Research Journals

 

Full Length Research Paper

Prevalence and risk factors of community-acquired urinary tract infections due to ESBL-producing Gram negative bacteria in an Armed Forces Hospital in Sothern Saudi Arabia

TA El-Kersh1*, MA Marie1, YA Al-Sheikh1, and SA Al-Kahtani2

1Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia
2Armed Forces Hospital Southern Region (AFHSR) Khamis Mushayt, Saudi Arabia

*Corresponding Author E-mail: talatkersh@yahoo.com; tkersh@ksu.edu.sa; Tel: +966114693734; Fax: +966114693738

Accepted 04 August, 2015

Abstract

This study investigated the prevalence and Antibiotic sensitivity profiles of Gram negative bacteria (GNB) isolated from urine specimens of out-patients with urinary tract infections (CA-UTI) in Armed Forces Hospital in southern Saudi Arabia, risk factors for infection, and extended spectrum β-lactamase production (ESBLs). The Vitek2 system (BioMe´rieux, France), was used for microbial identification, susceptibility testing, and ESBL detection, which was also confirmed by the Clinical and Laboratory Standards Institute  double-disk synergy test. A total of 269 GNB were studied.  E. coli accounted for 77 % (206/269), Klebsiella pneumoniae for 16 % (43/269) and other GNB 7% (20/269).   Fifty four % (23/43) of K. pneumoniae and 44% (91/206) of E coli isolates, were ESBL positive. Females comprised 74% (200/269) of patients, and 14% (37/269) were pregnant. Patients aged ≤10 years and those aged 71-80 years showed significant high risk to CA-UTI at frequency of 20.4 % (55/269) and 24.9 %(67/269) respectively. Unlike pregnancy, diabetic, cardiac, and/or renal disease-patients showed also high risk to CA-UTI by K. pneumonia.  E. coli, K. pneumoniae and other GNB susceptibility against meropenem, amikacin and gentamicin were 99%, 95 % and 85%; 88%, 88 % and 75%; and 75 %, 60 % and 70% respectively. While 53% and 25% of E coli isolates were resistant to TMP/SMZ and nitrofurantoin respectively. Seven Eterobacteriaceae isolates (E coli, 2; K pneumonia, 2; Serratia marcescens, 2 and Citrobacter freundii, 1) were resistant to all tested 14 drugs (pan-resistant isolates). Our findings identified risk factors which can be used to guide appropriate empiric therapy of CA-UTI, and targeted infection control measures.

Keywords: Community UTI, Risk factors, Vitek2, ESBL, pan-resistant isolates, E. coli, K. pneumoniae

Related Articles


Original Research Article
Herruzo R, Ruiz G, Burgos C, Perez-Blanco V, Gallego S, Mora E, Omenaca F
If you are looking for you can find endemic bla-VIM gene microorganisms, in Children's Hospitals
Glo. Adv. Res. J. Med. Med. Sci. May 2016 Vol: 5(4): - [Abstract] [Full Text - PDF] (280 KB)
Case Report
Nisa Félix and Fátima Palma
Caroli’s disease: management of a rare condition during pregnancy
Glo. Adv. Res. J. Med. Med. Sci. July 2017 Vol: 6(7): - [Abstract] [Full Text - PDF] (969 KB)
Original Research Articles
Nwafor O Emmanuel
Antimicrobial activities of extract of four local spices on bacteria isolated from raw meat sold in Abraka Delta State Nigeria
Glo. Adv. Res. J. Med. Med. Sci. April 2013 Vol: 2(2): - [Abstract] [Full Text - PDF] (351 KB)
Rafael Herruzo, Maria Jose Vizcaino, Irene Herruzo, Edward Mora
Evaluation of the different diffusion capacity from a contaminated zone to adjacent areas, of two epidemic strains of K. pneumoniae OXA48–carbepenemase, using detergents or disinfectants, applied with used or unused microfiber-cloth
Glo. Adv. Res. J. Med. Med. Sci. June 2016 Vol: 5(5): - [Abstract] [Full Text - PDF] (505 KB)
Zia Ur Rahman Awan, Abdul Haleem Shah, Hafiz Munib Ur Rahman, and Sanaullah Khan
Hepatitis C Virus infection in IDPs of war against terrorism in South Waziristan Agency, Pakistan
Glo. Adv. Res. J. Med. Med. Sci. September 2012 Vol: 1(2): - [Abstract] [Full Text - PDF] (714 KB)
W. Braide, S.U.Oranusi, C.K. Akaluka , R.N.Nwaoguikpe, C.I. Akobundu and N.I. Peter-Ikechukwu
Antibacterial efficacy of crude and diluted honey on four wound isolates
Glo. Adv. Res. J. Med. Med. Sci. February 2012 Vol: 1(1): - [Abstract] [Full Text - PDF] (65 KB)

Current Issue

Viewing Options

View Full Article - PDF
Download Full Article - PDF

Search for Articles

El-Kersh TA on Google Scholar
El-Kersh TA on Pubmed
Marie MA on Google Scholar
Marie MA on Pubmed
Al-Sheikh YA on Google Scholar
Al-Sheikh YA on Pubmed
Al-Kahtani SA on Google Scholar
Al-Kahtani SA on Pubmed

Statistics

Viewed 4004
Printed 1916
Downloaded 2456
Powered By iPortal Works