Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
September 2014 Vol. 3(9), pp. 251-261
Copyright © 2014 Global Advanced Research Journals

 

Full Length Research Paper

Copper (I)-Nicotinate Complex Exhibits More Prophylactic Effect than Butylated hydroxytoluene Against Nephrotoxicity in Chronically Aflatoxicosed Rats

Ahmed Y. Nassar1, Ahmed M. Ali2*, Allam A. Nafady3, Mona A. El-Baz1, Yousif S. Mohamed4, Fathy F. Abdel Latif4, Abdel Haleem M. Hussein2 and Muammar Y. Nassar5

1Department of Biochemistry, Faculty of Medicine-Assiut University - Egypt.
2Department of Chemistry, Faculty of Science-Al-Azhar University-Assiut Branch-Egypt.
3Department of Patholoy, Faculty of Veterinary Medicine- Assiut University - Egypt.
4Department of Chemistry, Faculty of Science- Minia University - Egypt.
5Department of Biochemistry, Dongola University - Sudan.

*Corresponding Author E-mail: ahmedshatat82@yahoo.com; Phone: +2 01006785228

Accepted 11 September, 2014

Abstract

This submitted work was designed in order to evaluate the prophylactive efficacy of the synthetic copper (I)-nicotinate complex against nephrotoxicity by aflatoxin B1 (AFB1) with regard to the highly accepted antioxidant agent butylated hydroxytoluene (BHT). Aflatoxin B1 fraction was obtained by growing Aspergillus flavus in potato dextrose agar (PDB) liquid medium. Healthy young males albino rats (n=45) were exposed to AFB1 day after day for five weeks (20 µg/kg body weight). One third of them was co-treated with BHT (0.05 g/kg body weight) and the second third by the copper complex (400 µg/kg body weight) while the third was considered as only intoxicated control group. Such intoxication resulted into the histopathological (light and electron transmission) characteristic features of nephrotoxicity. The sever degenerative changes swelling of the cells even rapture of the membrane and cellular organelles in the tubular lumen as well as fibrocytic reaction and congestion of the vasculature in addition to glomerular reaction manifested by atrophy of both vesiral (bodocyte) and parital shirnked cells. The co-treated BHT group did not eliminate all such features of degenerative characters in intoxicated tissue kidney while the co-treated copper complex group mostly appeared normal. The enzyme level of phase II of body detoxificating GST was significantly increased than that improved by BHT. Conclusively, the food additive probable use of the copper nicotinate complex could be a promising agent against nephrotoxicosis.

Keyword: Aflatoxin B1, copper (I)-nicotinate complex, Butylated hydroxytoluene, Nephrotoxicity, Antioxidant, Food additive.

 

Related Articles


Original Research Articles
Mohamed H. M. Abd El Azim, Mohamed El-Gerby, Ahmed A. M. Abdelgawad, Amani M. D. El-Mesallamy
Some Biological Effects of the Phenolic Content of Licorice Roots (Glycyrrhiza glabra L.)
Glo. Adv. Res. J. Med. Med. Sci. February 2016 Vol: 5(2): - [Abstract] [Full Text - PDF] (220 KB)
Wafaa El-komy1, Soheir Mahmoud1, Hoda Sabry1, Soheir Mansy2 and Nevine Guirguis1
Changes in parasitic load, phagocytosis and ultra-structural pattern in experimental cryptosporidiosis following combined (Antox and Nitazode) treatment
Glo. Adv. Res. J. Med. Med. Sci. March 2016 Vol: 5(3): - [Abstract] [Full Text - PDF] (3,544 KB)
S Pombal, J Rodilla, A Gomes, L. Silva, P Rocha
Evaluation of the antibacterial activity of the essential oil and antioxidant activity of aqueous extracts of the Eucalyptus globulus Labill. leaves
Glo. Adv. Res. J. Med. Med. Sci. November 2014 Vol: 3(11): - [Abstract] [Full Text - PDF] (326 KB)
Nadia Mahmoud Mohamed Al Rouby and Raeesa Abdel Tawab Mohamed
Reversibility of Diabetic Cardiac Changes in Albino Rats by Insulin Glargine Treatment
Glo. Adv. Res. J. Med. Med. Sci. April 2015 Vol: 4(4): - [Abstract] [Full Text - PDF] (2,320 KB)
Gamil El-Sayed Ibrahima and Azza Ezz Al-Majed
y-Irradiation and Maillard reaction products (MRPs) effect on phenolic content, antiradical and volatile compounds of Sewi dates
Glo. Adv. Res. J. Med. Med. Sci. October 2015 Vol: 4(10): - [Abstract] [Full Text - PDF] (698 KB)
Valeria Pasciu, Elena Baralla, Maria Vittoria Varoni, Tiziana Sedda, Gianpiero Boatto, Maria Nieddu, Lucia Burrai and Maria Piera Demontis
Preliminary analysis of oxidative stress parameters in Lister Hooded rats after an acute oral treatment with 2,5-dimethoxyamphetamine
Glo. Adv. Res. J. Med. Med. Sci. August 2015 Vol: 4(8): - [Abstract] [Full Text - PDF] (211 KB)

Current Issue

Viewing Options

View Full Article - PDF
Download Full Article - PDF

Search for Articles

Ahmed Y Nassar on Google Scholar
Ahmed Y Nassar on Pubmed
Ahmed M Ali on Google Scholar
Ahmed M Ali on Pubmed
Allam A Nafady on Google Scholar
Allam A Nafady on Pubmed
Mona A El-Baz on Google Scholar
Mona A El-Baz on Pubmed
Yousif S Mohamed on Google Scholar
Yousif S Mohamed on Pubmed
Fathy F Abdel Latif on Google Scholar
Fathy F Abdel Latif on Pubmed
Abdel Haleem M Hussein on Google Scholar
Abdel Haleem M Hussein on Pubmed
Muammar Y Nassar on Google Scholar
Muammar Y Nassar on Pubmed

Statistics

Viewed 1099
Printed 246
Downloaded 891
Powered By iPortal Works