Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
September 2014 Vol. 3(9), pp. 251-261
Copyright © 2014 Global Advanced Research Journals

 

Full Length Research Paper

Copper (I)-Nicotinate Complex Exhibits More Prophylactic Effect than Butylated hydroxytoluene Against Nephrotoxicity in Chronically Aflatoxicosed Rats

Ahmed Y. Nassar1, Ahmed M. Ali2*, Allam A. Nafady3, Mona A. El-Baz1, Yousif S. Mohamed4, Fathy F. Abdel Latif4, Abdel Haleem M. Hussein2 and Muammar Y. Nassar5

1Department of Biochemistry, Faculty of Medicine-Assiut University - Egypt.
2Department of Chemistry, Faculty of Science-Al-Azhar University-Assiut Branch-Egypt.
3Department of Patholoy, Faculty of Veterinary Medicine- Assiut University - Egypt.
4Department of Chemistry, Faculty of Science- Minia University - Egypt.
5Department of Biochemistry, Dongola University - Sudan.

*Corresponding Author E-mail: ahmedshatat82@yahoo.com; Phone: +2 01006785228

Accepted 11 September, 2014

Abstract

This submitted work was designed in order to evaluate the prophylactive efficacy of the synthetic copper (I)-nicotinate complex against nephrotoxicity by aflatoxin B1 (AFB1) with regard to the highly accepted antioxidant agent butylated hydroxytoluene (BHT). Aflatoxin B1 fraction was obtained by growing Aspergillus flavus in potato dextrose agar (PDB) liquid medium. Healthy young males albino rats (n=45) were exposed to AFB1 day after day for five weeks (20 µg/kg body weight). One third of them was co-treated with BHT (0.05 g/kg body weight) and the second third by the copper complex (400 µg/kg body weight) while the third was considered as only intoxicated control group. Such intoxication resulted into the histopathological (light and electron transmission) characteristic features of nephrotoxicity. The sever degenerative changes swelling of the cells even rapture of the membrane and cellular organelles in the tubular lumen as well as fibrocytic reaction and congestion of the vasculature in addition to glomerular reaction manifested by atrophy of both vesiral (bodocyte) and parital shirnked cells. The co-treated BHT group did not eliminate all such features of degenerative characters in intoxicated tissue kidney while the co-treated copper complex group mostly appeared normal. The enzyme level of phase II of body detoxificating GST was significantly increased than that improved by BHT. Conclusively, the food additive probable use of the copper nicotinate complex could be a promising agent against nephrotoxicosis.

Keyword: Aflatoxin B1, copper (I)-nicotinate complex, Butylated hydroxytoluene, Nephrotoxicity, Antioxidant, Food additive.

 

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