Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
September 2014 Vol. 3(9), pp. 233-239
Copyright © 2014 Global Advanced Research Journals
Full Length Research Paper
Dexmedetomidine and Remifentanil as Adjunct to Regional Anesthesia, a Randomized Clinical Trial
Dr. Nihal Kirman1, Dr. Ömer Burak Küçükebe2, Dr. Ruslan Abdullayev2*, Dr. Esra Aksoy3 and Assoc. Prof. Dr. Nermin Göğüş4
1İzmir Tepecik Research Hospital, Anesthesiology and Reanimation Department İzmir, Turkey.
2Adiyaman University Research Hospital, Anesthesiology and Reanimation Department.
3Ankara Numune Research Hospital, Anesthesiology and Reanimation Department, Ankara, Turkey.
4Hitit University Medical Faculty, Anesthesiology and Reanimation Department, Ankara, Turkey.
Accepted 02 September, 2014
Spinal anesthesia is one of the required methods for orthopedic surgery. It is of quite importance to decrease anxiety of awake patient during an operation under spinal anesthesia. Plenty of drugs have been used for this purpose. We aimed to compare dexmedetomidine and remifentanil administered for sedation and evaluate it by OAA/S and BIS. Patients aged 18-65 years undergoing orthopedic knee surgery under spinal anesthesia were divided into two groups. Group D received dexmedetomidine 1 µg/kg bolus, then 0.2 µg/kg/h infusion; group R received remifentanil 0.5 µg/kg bolus, then 3 µg/kg/h infusion. Hemodynamic variables and respiratory parameters were recorded. Sedation level was measured by OAA/S and BIS. There was no marked difference in hemodynamic parameters between the two groups, but group D had higher OAA/S and lower BIS scores. Although respiration was depressed more in group R, recovery time was shorter in group D. Both remifentanil and dexmedetomidine can be used for sedation provided that the respiratory parameters are monitored. While faster recovery was provided by remifentanil, deeper sedation was achieved by dexmedetomidine.
Keywords: BIS, dexmedetomidine, remifentanil, sedation, OAA/S.
- Nihal Kirman on Google Scholar
- Nihal Kirman on Pubmed
- Ömer Burak Küçükebe on Google Scholar
- Ömer Burak Küçükebe on Pubmed
- Ruslan Abdullayev on Google Scholar
- Ruslan Abdullayev on Pubmed
- Esra Aksoy on Google Scholar
- Esra Aksoy on Pubmed
- Nermin Göğüş on Google Scholar
- Nermin Göğüş on Pubmed