Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
September 2015 Vol. 4(9), pp. 389-393
Copyright © 2015 Global Advanced Research Journals


Full Length Research Paper

What is the first clinical manifestation in multiple sclerosis patients?

Amin Elahifar1, Mohammad Taheri2, Mohammad Reza Mirinezhad3, Arezou Sayad2, Rezvan Noroozi2, Maryam Eghbali4 and Mehrdokht Mazdeh1*

1Department of Neurology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
2Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3Innovative medical research center, Mashhad branch, Islamic azad University, Mashhad, Iran.
4Department of medical genetics, school of medicine, Tehran University of medical sciences, Tehran, Iran.

*Corresponding Author E-mail:

Accepted 09 September, 2015


Multiple sclerosis is one of the most common neurologic diseases which has a growing prevalence. This disease is common among the young population and causes them sever neurological disability. Early diagnosis and treatment can reduce the number of attacks and their severity in patients and plays an important role in the enhancement of patients’ health level and their quality of life. As the primary clinical manifestations of MS are variable and nonspecific, and also different studies statistically have declared different comments about them, so in this study the prevalence of each possible primary clinical manifestation in MS patients of Hamadan is reviewed on the basis of age, sex and the type of clinical manifestation. In this study 500 MS cases who were referred to neurologic clinics and MS institute of Hamadan and had the entrance criteria were studied and a questionnaire including demographic information and most common primary clinical manifestations was completed for each of them. After that, the collected data was analyzed by SPSS 16 software. In this study 394 patient (78.8%) were female and 106 of them (21.2%) were male. The study population had a pic range of 20-40 years old in their age. Mean age in onset of MS was 29.4±8.7 (min age of 11 and max age of 62 years old). The most common primary clinical manifestations of MS were visual symptoms in 31.6%, sensory symptoms in 19.8%, balance symptoms in 16.7%, and motor symptoms in 13.8% of the patients respectively. No significant difference was seen between the prevalence of primary clinical manifestations between males and females. In this study, visual symptoms (optic neuritis and diplopia) were the most common primary clinical manifestations in all age ranges of the study population of MS patients followed by sensory symptoms as the second common primary clinical manifestations. As a conclusion, these results show the necessity of medical team alertness including General Physicians, neurologists and ophthalmologists about early diagnosis of MS. It is recommended to perform studies with more extended population involved in order to have a more reliable comparison between the prevalence of MS clinical manifestations on the basis of their age, sex and location.

Keywords: Multiple Sclerosis, first, clinical manifestation.


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