Global Advanced Research Journal of Pharmacy and Pharmacology (GARJPP)
October 2013 Vol. 2(1), pp. 002-012
Copyright © 2013 Global Advanced Research Journals

 

Review

Pathophysiology of obesity: Focused, cause-driven approach to control the epidemic

Sunil Wimalawansa, MD, PhD, MBA, DSc

Cardio Metabolic Institute, 51 Veronica Avenue, Somerset, New Jersey, 08873, USA

E-mail: wimalawansa1@hotmail.com

Accepted 9 October, 2013

Abstract

Obesity is a disease with serious public health and economic outcomes.  It is more than simply a thermodynamic, genetic, or a metabolic problem of handling calories; it is a behavioral disorder and an inflammatory disease leading to dysregulation of metabolism and energy balance, and impairment of the neurohormonal systems, leading to accumulation of intra-abdominal fat leading to serious complications.  Obesity rates as indicated by the increasing body mass index (BMI) or by abdominal girth are escalating in the United States and most industrialized countries. Approximately two-thirds of these patients develop complications that would cost billions of taxpayer dollars.  However, in Asians BMI is less relevant and the increasing abdominal girth is a better indicator that reflect accumulation of the visceral fat; the most detrimental for the health.  Obesity is a multi-factorial disease for which genetics, environment, behavioral, physical and other factors contribute to the development.  Those who are obese and sick and unhealthy, secondary to accumulation of excessive visceral fat are at high risk of developing complications.  At the current rates, it is predicted that obesity-associated deaths are going to surpass cardiovascular deaths within the next two decades.  For the majority of overweight and obese people, it is necessary to reduce only seven to ten percent of their body weight via calorie-reduced diet and increasing physical activity that would improve the metabolism and decrease potential complications and premature deaths.  In addition to reasonable weight reduction programs, controlling the obesity-associated complications requires coordinated, cause-driven, and complication-centric approaches.  Understanding the cause for the obesity in each patient would greatly facilitate the development of an individualized, sustainable, and successful treatment plan.  Therefore, the multi-factorial nature of engender obesity needs a focused, specific, cause-driven approaches to combat.  Considering the high cost of managing obesity, type 2 diabetes and their complications, prevention of obesity is the way forward that is based on causes and risk factors.  This is one of the most cost-effective approaches to decrease the obesity-associated complications, morbidities and premature deaths.

Keywords: metabolism, epidemic, adepokines, body mass index (BMI), cardiovascular, morbidity, overweight.

Related Articles


Original Research Articles
Ibrahim Shah, Shahzeb, Mohammad Hafizullah, Syed Tahir Shah, Mohammad Faheem, Rafiullah
Peripartum cardiomyopathy: risk factors, hospital course and prognosis; experiences at Lady Reading Hospital Peshawar
Glo. Adv. Res. J. Pharm. Pharmacol. September 2012 Vol: 1(1): - [Abstract] [Full Text - PDF] (206 KB)
Ernest Emilion and Richard Emilion
Screening over weight and diabetic women from serum 25- hydroxy vitamin D and serumthyroid-stimulating hormone levels with Age, Body Mass Index and Fast Plasma Glucose
Glo. Adv. Res. J. Pharm. Pharmacol. June 2015 Vol: 4(5): - [Abstract] [Full Text - PDF] (147 KB)
Oguntona SA and Ogunsemi OO
Plantar Fasciitis among Nigerians
Glo. Adv. Res. J. Pharm. Pharmacol. March 2013 Vol: 2(3): - [Abstract] [Full Text - PDF] (127 KB)
Reem Bahmaid and Nahid El-Bakri
Ivabradine for Treatment of Stable Angina and Heart Failure
Glo. Adv. Res. J. Pharm. Pharmacol. December 2016 Vol: 5(12): - [Abstract] [Full Text - PDF] (124 KB)
Nisreen Haj, Mohamed Yousef, Elsafi Ahmed, Ikhlas Abdelaziz, Duha Abdu and Muna Ahmed
Assessment of Echocardiographic Imaging in Diagnosis of Heart Failure
Glo. Adv. Res. J. Pharm. Pharmacol. August 2017 Vol: 6(8): - [Abstract] [Full Text - PDF] (126 KB)
Rafael Herruzo, Maria Jose Vizcaino, Irene Herruzo, Edward Mora
Evaluation of the different diffusion capacity from a contaminated zone to adjacent areas, of two epidemic strains of K. pneumoniae OXA48–carbepenemase, using detergents or disinfectants, applied with used or unused microfiber-cloth
Glo. Adv. Res. J. Pharm. Pharmacol. June 2016 Vol: 5(5): - [Abstract] [Full Text - PDF] (505 KB)

Current Issue

Viewing Options

View Full Article - PDF
Download Full Article - PDF

Search for Articles

Sunil Wimalawansa on Google Scholar
Sunil Wimalawansa on Pubmed

Statistics

Viewed 1133
Printed 239
Downloaded 489
Powered By iPortal Works