Global Advanced Research Journal of Pharmacy and Pharmacology (GARJPP)
November 2013 Vol. 2(2), pp. 021-032
Copyright © 2013 Global Advanced Research Journals

 

Full Length Research Paper

Effects of metformin, or metformin with omega 3 combination on serum leptin in Iraqi obese subjects

Afrah M Al-Helli*, Mustafa G. Al-Abbassi, Mohamed A. Al-Biaty

Al-Mustansiriyah University College of Pharmacy, Baghdad, Iraq

*Corresponding Authors E-mail: afrahalhelli@yahoo.com

Accepted 28 October, 2013

Abstract

Obesity is an excessive development of fat throughout the body in which a body mass index (BMI) is over 30.According to the world health organization (WHO) reports, obesity is a global epidemic throughout the world. Iraq is in the seventh rank of the prevalence of obesity in the world. In this research we aim to study the effects of metformin and omega 3 drugs alone or their combination on BMI, fasting blood glucose, lipid profile, liver enzymes (ALT, AST), Malondiadehyde (MDA), and leptin. In this research we have thirty six obese subjects and divided into three groupsthese subjects were selected from the Al-Kindi Medical College, obesity research and therapeutic unit where they were visiting the unit for treatment.The first group used metformin 1500 mg/day for two months, and the second group used placebo drug once daily for two months. The third group used metformin 1500 mg/day plus omega 3 for the same period. The finding of the research imply that the comparison between the second treated group and the third treated group showed a significant change in this study parameters (p<0.05). However, in comparison between the second group with the first treated group showed a significant change in the study parameters (p<0.05). Comparison the first treated group with thethird treated group showed no significant change (p>0.05) except with triglyceride, MDA parameters (p<0.05). In general, it can be concluded that metformin plus omega 3 by far is the best choice for obese subjects in this study.

Keywords: obesity, metformin, omega 3, BMI, leptin

 

Related Articles


Original Research Article
Ali Taha A Hassan, Hossam El-Din M Omar, Nagwa M Elsawi and Amira M Ahmed
Evaluation of serum cortisol, growth and thyroid hormones and its relation with lipolysis in non-diabetic obese and diabetic obese subjects attending Sohag Governorate, Egypt
Glo. Adv. Res. J. Pharm. Pharmacol. April 2016 Vol: 5(4): - [Abstract] [Full Text - PDF] (156 KB)
Review
Sunil Wimalawansa
Pathophysiology of obesity: Focused, cause-driven approach to control the epidemic
Glo. Adv. Res. J. Pharm. Pharmacol. October 2013 Vol: 2(1): - [Abstract] [Full Text - PDF] (605 KB)
Original Research Article
Maria Agolli and Roven Sinani
Assessment of level of breathing difficulty in Obese Children
Glo. Adv. Res. J. Pharm. Pharmacol. June 2012 Vol: 1(5): - [Abstract] [Full Text - PDF] (131 KB)
Review
Marcelo Porto, Kazuo Kawano Nagamine, Antonio Carlos Brandão, Dorotéia Rossi Silva Souza and Cassiano Merussi Neiva
Updating on resistance training for prepubertal obese children: Resistance training for obese children
Glo. Adv. Res. J. Pharm. Pharmacol. December 2012 Vol: 1(11): - [Abstract] [Full Text - PDF] (205 KB)
Original Research Articles
Vitaly Tchirkov, Naby Moussa Balde, Mandiou Diakite
Main causes of noncommunicable diseases in Guinea: a study in medical students of the University of Conakry
Glo. Adv. Res. J. Pharm. Pharmacol. September 2018 Vol: 7(7): - [Abstract] [Full Text - PDF] (126 KB)
Sihem Souissi, Fethi Ben Slama, Asma Ayed, Habib Askri, Tohami khelifi, Nabil Guermezi and Omrane Belhadj
The relationship between physical inactivity and bad snacking on metabolic syndrome
Glo. Adv. Res. J. Pharm. Pharmacol. May 2016 Vol: 5(5): - [Abstract] [Full Text - PDF] (128 KB)

Current Issue

Viewing Options

View Full Article - PDF
Download Full Article - PDF

Search for Articles

Afrah M Al-Helli on Google Scholar
Afrah M Al-Helli on Pubmed
Mustafa G Al-Abbassi on Google Scholar
Mustafa G Al-Abbassi on Pubmed
Mohamed A Al-Biaty on Google Scholar
Mohamed A Al-Biaty on Pubmed

Statistics

Viewed 988
Printed 195
Downloaded 418
Powered By iPortal Works