Global Advanced Research Journal of Pharmacy and Pharmacology (GARJPP)
November 2013 Vol. 2(2), pp. 021-032
Copyright © 2013 Global Advanced Research Journals

 

Full Length Research Paper

Effects of metformin, or metformin with omega 3 combination on serum leptin in Iraqi obese subjects

Afrah M Al-Helli*, Mustafa G. Al-Abbassi, Mohamed A. Al-Biaty

Al-Mustansiriyah University College of Pharmacy, Baghdad, Iraq

*Corresponding Authors E-mail: afrahalhelli@yahoo.com

Accepted 28 October, 2013

Abstract

Obesity is an excessive development of fat throughout the body in which a body mass index (BMI) is over 30.According to the world health organization (WHO) reports, obesity is a global epidemic throughout the world. Iraq is in the seventh rank of the prevalence of obesity in the world. In this research we aim to study the effects of metformin and omega 3 drugs alone or their combination on BMI, fasting blood glucose, lipid profile, liver enzymes (ALT, AST), Malondiadehyde (MDA), and leptin. In this research we have thirty six obese subjects and divided into three groupsthese subjects were selected from the Al-Kindi Medical College, obesity research and therapeutic unit where they were visiting the unit for treatment.The first group used metformin 1500 mg/day for two months, and the second group used placebo drug once daily for two months. The third group used metformin 1500 mg/day plus omega 3 for the same period. The finding of the research imply that the comparison between the second treated group and the third treated group showed a significant change in this study parameters (p<0.05). However, in comparison between the second group with the first treated group showed a significant change in the study parameters (p<0.05). Comparison the first treated group with thethird treated group showed no significant change (p>0.05) except with triglyceride, MDA parameters (p<0.05). In general, it can be concluded that metformin plus omega 3 by far is the best choice for obese subjects in this study.

Keywords: obesity, metformin, omega 3, BMI, leptin

 

Related Articles


Review
Sunil Wimalawansa
Pathophysiology of obesity: Focused, cause-driven approach to control the epidemic
Glo. Adv. Res. J. Pharm. Pharmacol. October 2013 Vol: 2(1): - [Abstract] [Full Text - PDF] (605 KB)
Original Research Articles
Marta Reis, LĂșcia Ramiro, Emmanuelle Godeau, Margarida Gaspar de Matos, & Aventura Social
Age at menarche in Portuguese adolescents - A cross-sectional study with HBSC Portuguese survey
Glo. Adv. Res. J. Pharm. Pharmacol. April 2016 Vol: 5(4): - [Abstract] [Full Text - PDF] (391 KB)
Awosan KJ, Ibrahim MTO, Arisegi SA, Ejimadu SP, Erhiano EE, Aderahman AT
Prevalence of metabolic syndrome and its components among civil servants in a metropolitan city in Northern Nigeria
Glo. Adv. Res. J. Pharm. Pharmacol. November 2013 Vol: 2(11): - [Abstract] [Full Text - PDF] (178 KB)
Elsawi NM, Omar HM, Hassan AA and Ahmed AM
Study of C- peptide and glycoslated hemoglobin in obese and obese with type 2 diabetes and its relation with lipid profile from Sohag Governarate-Egypt
Glo. Adv. Res. J. Pharm. Pharmacol. December 2014 Vol: 3(12): - [Abstract] [Full Text - PDF] (147 KB)
Peter R Berti, Elena Villacrés, Gabriela Segovia, Nelson Mazon, Eduardo Peralta.
Lupinus mutabilis Sweet, a traditional Ecuadorian grain: Fatty acid composition, use in the Ecuadorian food system, and potential for reducing malnutrition.
Glo. Adv. Res. J. Pharm. Pharmacol. June 2013 Vol: 2(6): - [Abstract] [Full Text - PDF] (230 KB)
Baba Usman Ahmadu, Ngilari Maigana Usiju, Ahmad Ibrahim, Apagu Adamu Adiel, Delia Tumba, Musa Rimamchika, Joshua Danji Solomon
Lingering hunger among primary school pupils residing in rural areas of Borno State North Eastern Nigeria implication for education and food supplementation programs
Glo. Adv. Res. J. Pharm. Pharmacol. December 2012 Vol: 1(7): - [Abstract] [Full Text - PDF] (147 KB)

Current Issue

Viewing Options

View Full Article - PDF
Download Full Article - PDF

Search for Articles

Afrah M Al-Helli on Google Scholar
Afrah M Al-Helli on Pubmed
Mustafa G Al-Abbassi on Google Scholar
Mustafa G Al-Abbassi on Pubmed
Mohamed A Al-Biaty on Google Scholar
Mohamed A Al-Biaty on Pubmed

Statistics

Viewed 456
Printed 110
Downloaded 249
Powered By iPortal Works