Global Advanced Research Journal of Medicine and Medical Sciences (GARJMMS) ISSN: 2315-5159
December 2015 Special Issue Vol. 4(12), pp. 520-524
Copyright © 2015 Global Advanced Research Journals


Full Length Research Paper

Analysis of Thiamine prescription rates in a tertiary hospital setting

Dr. Ali M Alhaddad1, Dr. Karen Boland MRCPI1,2* and Professor Frank E Murray FRCPI2

1Royal College of Surgeons in Ireland, 123 St Stephens Green, Dublin 2
2Department of Gastroenterology and Hepatology, Beaumont Hospital, Dublin 9,01 4028518

*Corresponding  Author  E-mail:; Phone: 01 4028518

Accepted 07 December, 2015


Thiamine, or Vitamin B1 is a water soluble vitamin, essential for the normal growth and development of our nervous systems. It is also an essential cofactor for enzymes crucial to metabolic homeostasis. Vulnerable patient groups, particularly those with a alcohol dependence syndrome, alcohol withdrawal syndrome and malnourished patient groups have been identified as being at risk of thiamine deficiency, and hence Wernicke's Encephalopathy. This is a debilitating neuropsychiatric disease characterized as a triad of gait ataxia, ophthalmoplegia, and confusion. Our aim was to assess thiamine prescription rates and compliance to the NICE guidelines with regard to supplementation of thiamine in patients at risk of Wernicke's Encephalopathy. In June, 2102 Beaumont Hospital we completed a retrospective audit on the kardexes of 240 patients admitted over the previous 31 days in Beaumont Hospital over four weeks. Only 28 patients had been prescribed thiamine during their admission. We noted incomplete documentation of the indications for thiamine prescription in the medical notes and variation in the dosing and duration of prescribed regimens. Our results indicate that education is needed in the area of thiamine supplementation among healthcare workers to ensure best practice and patient care.

Keywords: Thiamine, Vitamin B1,  Alcohol withdrawal,  Dependence syndrome

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